Childhood adversity and cannabis use were linked to psychosis risk and course
A systematic review examined their co-occurrence across community and clinical populations, reporting associations with psychosis risk and less favorable outcomes among affected patients.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The review reported associations between combined childhood adversity and cannabis exposure and psychosis risk, earlier onset and poorer clinical outcomes. These findings describe patterns across different populations, rather than an individual prediction. The abstract does not establish that the combined exposures caused psychosis, quantify a typical effect, or demonstrate that a particular intervention improves outcomes.
The abstract highlights maximum odds ratios without their confidence intervals or clearly defined reference groups. It also gives limited detail about study quality and intervention results, preventing a reliable estimate of typical risk or treatment benefit.
Risk and course are different questions
Community studies examined psychosis risk, while clinical studies also addressed onset, symptoms, treatment response and functioning. These outcomes should remain distinct: an association with developing psychosis is not the same as an association with its course.
Mechanisms remain an interpretation
The authors discussed stress-response, inflammatory and endocannabinoid mechanisms and described integrated trauma and substance-use interventions as promising. The abstract does not establish the proposed biological pathway or provide enough intervention evidence to judge effectiveness.
The original publication
Co-occurrence between adverse childhood experiences and cannabis use in psychosis risk and course: A stratified systematic review.
Ricci V, De Berardis D, Martinotti G et al.
J Psychiatr Res · 2025
- PubMed ID
- 40834620
- Record checked
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