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Stimulation review finds better leg-function scores after stroke

Pooled results favored intermittent theta burst stimulation for movement, balance and daily activities, but some measures and subgroup results remained uncertain.

By 100HP editorialAbstract-based explanation checked

Based on the published abstract. The full paper may contain additional methods, results and limitations.

The 30-second takeaway

The pooled results suggest that intermittent theta burst stimulation may improve measured leg function after stroke. Balance and daily-activity scores also favored stimulation. However, one stimulation-site subgroup showed no statistically significant improvement in leg function or balance. This leaves uncertainty about how consistently the overall findings apply across stimulation approaches.

Keep in mind

The abstract omits treatment duration, control treatments and whether score improvements were noticeable to patients. Abstract-only access limits assessment of practical benefit.

THE NUMBERS, WITH CONTEXT

What researchers found

Mean difference: 2.31 score points; 95% confidence interval: 0.78–3.84

Leg motor function, measured with FMA-LE

The between-group difference favored stimulation over controls. The interval describes uncertainty around the estimated difference. Assessment timing was not reported in the abstract.

Clin Neurol Neurosurg, 2025 · Original source ↓

Separate measures of recovery

The review assessed leg movement, balance and daily activities separately. A higher movement score alone does not tell readers how much a person's everyday independence changed after treatment.

Some results remained uncertain

Central motor conduction time shortened, while motor-evoked potential latency showed no statistically significant improvement. These physiological measurements are distinct from daily functioning, and a nonsignificant result does not establish absence of an effect.

CHECK THE ORIGINAL

The original publication

Effects of intermittent theta burst stimulation on lower limb motor function in stroke patients: A systematic review and meta-analysis.

Zhao H, Zhou Y, Long Y et al.
Clin Neurol Neurosurg · 2025

PubMed ID
40840160
Record checked

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