Trial pill-taking patterns were associated with progression to psychosis
An exploratory analysis linked lower adherence to study capsules with later psychosis, regardless of whether participants received fish oil or placebo.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Participants who took less of their assigned study medication were more likely to progress to psychosis. The association remained after adjustment for several measured factors and was independent of treatment assignment. Because adherence itself was not randomly assigned, these findings cannot show that taking the capsules prevented psychosis or that fish oil was effective.
This abstract-based analysis cannot establish why adherence and psychosis were related. The psychosis assessment timeframe is unspecified, and statistical adjustment does not turn the adherence comparison into a causal test.
What researchers found
Progression to psychosis
Non-adherent versus adherent participants; the association persisted in adjusted analysis. Adherence covered 6 months, but the psychosis follow-up interval was not reported.
What adherence meant
Researchers classified participants by how consistently they took the assigned capsules. They also checked a definition based on returned pills. Both approaches linked non-adherence with progression, suggesting the observation was not limited to a single definition.
A possible marker
Non-adherence was also associated with smoking, cannabis use, functioning, and symptom history. These connections make pill-taking behavior potentially informative about risk, but the abstract does not establish the pathway connecting that behavior with psychosis.
The original publication
Association between non-adherence to fish oil or placebo as a risk factor of transition to psychosis in ultra-high-risk individuals in the NEURAPRO study.
Schlögelhofer M, Lin A, Markulev C et al.
Aust N Z J Psychiatry · 2025
- PubMed ID
- 40855720
- Record checked
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