Adding flavonoids to vitamin C showed no clear platelet advantage in volunteers
Laboratory tests favored the combined supplement, but the human comparison found no statistically significant difference between supplements.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The combined supplement performed better in laboratory antioxidant and platelet tests, but that advantage was not demonstrated in healthy volunteers. Platelet reactivity to selected triggers decreased over time in both supplement groups, without significant differences between them. This does not prove equivalence, and the study did not establish a reduction in cardiovascular events.
The abstract omits participant numbers, human effect sizes, and detailed allocation methods. It reports platelet measurements rather than clinical outcomes, so the findings cannot establish prevention of heart attacks or other cardiovascular events.
What researchers found
Platelet reactivity
After 4 weeks, vitamin C plus bioflavonoids did not significantly differ from vitamin C alone on EC50-based platelet-reactivity measurements.
The laboratory findings were stronger
The combined product showed the strongest antioxidant capacity and laboratory effects on platelet aggregation among the tested supplements and mixtures. Those experiments suggested interactions between ingredients, but they did not establish a corresponding advantage in people.
Changes over time do not isolate added benefit
Platelet responses to selected triggers declined in both human study groups. The relevant comparison for the added flavonoids was the difference between groups, which was not statistically significant; the abstract provides no precise estimate of that difference.
The original publication
Anti-Inflammatory, Antithrombotic and Antioxidant Efficacy and Synergy of a High-Dose Vitamin C Supplement Enriched with a Low Dose of Bioflavonoids; In Vitro Assessment and In Vivo Evaluation Through a Clinical Study in Healthy Subjects.
Chrysikopoulou V, Rampaouni A, Koutsia E et al.
Nutrients · 2025
- PubMed ID
- 40871671
- Record checked
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