Oral hyaluronic acid shows mixed results across skin measures
A review of placebo-controlled trials reported improvements in some skin measurements, while other outcomes remained uncertain.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The pooled results favored oral hyaluronic acid for skin hydration, elasticity and wrinkle depth. Results for firmness, wrinkle volume and water loss through the skin were not statistically significant. This suggests a selective signal across measured skin properties, while leaving the size and practical importance of any benefit unclear.
The authors identify limited sample size and differences among studies. The abstract omits effect estimates, participant details and treatment durations, limiting assessment of how noticeable or broadly applicable the reported changes might be.
What researchers found
Skin hydration
Oral hyaluronic acid versus placebo in pooled trials; assessment timing and the standardized mean difference estimate were not reported in the abstract.
Several distinct outcomes
The review separated hydration, elasticity and wrinkle depth from firmness, wrinkle volume and skin water loss. Improvement in some measurements therefore does not establish improvement across every aspect of skin aging.
Uncertain size of benefit
The analysis used standardized mean differences to compare groups, but the abstract supplies no numerical estimates. Its description of favorable trends in nonsignificant outcomes does not establish that those outcomes improved with supplementation.
The original publication
Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction.
Amin P, Sarabi A, Choe S et al.
J Drugs Dermatol · 2025
- PubMed ID
- 40911749
- Record checked
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