Bone supplement review ranks changes in markers after menopause
Different supplements led different biomarker rankings, leaving the practical meaning for bone health uncertain.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The review ranked dietary supplements according to changes in bone turnover markers in postmenopausal women. Different supplements ranked highest for different markers, so the abstract does not identify a single overall winner. These biomarker rankings do not establish fewer fractures, stronger bones or slower progression of osteoporosis in everyday clinical care.
This abstract-based assessment has no treatment durations, effect sizes or uncertainty intervals to examine. The reported outcomes are biomarkers, so the authors' suggestion about limiting osteoporosis progression remains unproven here.
Different markers, different leaders
Vitamin E ranked highest for reducing the marker CTX. Combined vitamins D and K ranked highest for increasing the markers P1NP and osteocalcin; other supplements led rankings for other measured markers.
Interpreting the percentages
The abstract reports supplement rankings using SUCRA percentages, but does not give the sizes of biomarker differences. Those percentages cannot be read as reductions in fracture risk or as evidence of stronger bones.
The original publication
Effects of dietary supplements on bone turnover markers in women after menopause: a network meta-analysis.
Wei Y, Lei C, Zhong Y et al.
PeerJ · 2025
- PubMed ID
- 40949733
- Record checked
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