Candidate egg-quality biomarkers remain an assessment question in assisted reproduction
A review identified possible markers in follicular fluid and granulosa cells, but its abstract does not establish a validated test or improved reproductive outcomes.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The review identified candidate markers in follicular fluid and granulosa cells that may help researchers assess egg quality in assisted reproduction. It highlights oxidative-stress measurements and patterns of gene activity as promising avenues. The abstract does not show that using these markers improves embryo selection, pregnancy outcomes or the chances of having a baby.
The abstract provides no marker-specific accuracy estimates, testing thresholds or comparative reproductive outcomes. It is therefore insufficient to judge whether any candidate is ready for routine clinical assessment.
What researchers looked for
The review examined biological signals linked to egg maturation and quality. Examples included melatonin in follicular fluid, along with mitochondrial DNA and gene-activity signatures in granulosa cells. These were presented as candidates for further assessment.
Assessment is the question
The included research also considered cell appearance and DNA methylation. The review brings these approaches together as possible ways to assess quality, but the abstract does not rank their performance or demonstrate that combining them improves decisions.
The original publication
Biomarker candidates for oocyte and embryo quality assessment in assisted reproduction: A systematic review.
Molin EAD, Lazzari VM, Peruzzato FS et al.
JBRA Assist Reprod · 2025
- PubMed ID
- 40986714
- Record checked
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