Magnesium lowered blood pressure modestly on average across randomized trials
Results varied substantially, and the analysis found no clear dose–response relationship. Normal-blood-pressure groups did not reach statistical significance.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Magnesium supplementation produced modest average reductions in systolic and diastolic blood pressure compared with placebo. The review reported larger reductions in participants taking blood-pressure medication for hypertension and in those with low magnesium. Results varied substantially across studies, and the analysis did not identify a dose–response relationship or establish an optimal dose.
High variation between trials limits how well the pooled average describes any particular group. This abstract-based summary cannot establish cardiovascular benefits beyond the measured blood-pressure changes or resolve the best supplementation strategy.
What researchers found
Systolic blood-pressure change
Mean difference versus placebo; 95% CI -4.32 to -1.29. Median intervention duration: 12 weeks.
Different groups, different uncertainty
Blood-pressure reductions in participants with normal blood pressure did not reach statistical significance. This leaves uncertainty about the effect in that group; it should not be interpreted as proof that magnesium has no effect.
Dose was not a clear guide
The dose–response analysis did not show a reliable relationship between the amount of magnesium and the change in blood pressure. The abstract therefore offers no basis for claiming that a higher dose works better.
The original publication
Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Argeros Z, Xu X, Bhandari B et al.
Hypertension · 2025
- PubMed ID
- 41000008
- Record checked
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