Genetic trait scores show no clear overall link to psychiatric treatment outcomes
Across psychiatric cohorts, initial genetic signals did not survive multiple-testing correction, while analyses excluding particular diagnoses suggested possible differences worth investigating.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
None of the overall pooled associations met the study's threshold after adjustment for multiple testing. Cognitive trait scores showed some initial signals, and results changed when particular diagnostic groups were excluded. These findings leave open possible diagnosis-specific relationships, but they do not establish a dependable genetic predictor of treatment response across these disorders.
Outcomes were defined differently across cohorts, and the abstract does not give treatment details or follow-up periods. Associations between genetic scores and outcomes do not establish causation or usefulness for individual treatment decisions.
What researchers found
Statistically significant pooled treatment-outcome associations
Across genetic predisposition scores, for treatment resistance, remission and functioning; follow-up was not reported. No overall association survived multiple-testing correction.
The question across diagnoses
The analysis asked whether genetic predispositions to traits shared across diagnoses were associated with treatment outcomes. Researchers examined resistance to treatment, symptom remission and changes in functioning, using each cohort's available measures.
Why correction matters
Testing many associations can produce chance signals, so the researchers applied a stricter significance threshold. Some cognitive associations appeared when a diagnosis was excluded; those narrower analyses do not overturn the overall pooled result.
The original publication
Polygenic predisposition to transdiagnostic symptom dimensions and treatment outcomes across psychiatric disorders.
Abondio P, Fanelli G, Baldini V et al.
Prog Neuropsychopharmacol Biol Psychiatry · 2025
- PubMed ID
- 41022347
- Record checked
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