Curcuminoids plus piperine changed some lipid measures; LDL results were inconclusive
Pooled adult trials found changes in triglycerides, total cholesterol and HDL, while the LDL reduction was not statistically significant.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Across the included trials, curcuminoids combined with piperine reduced triglycerides and total cholesterol and increased HDL cholesterol on average. The LDL cholesterol result was not statistically significant. This abstract-based summary concerns blood lipid measurements; it does not show that the combination prevents cardiovascular disease or establish its place in treatment for an individual.
Reported outcomes were lipid levels, without evidence here on cardiovascular events. The abstract also gives limited detail about study quality and adverse effects, leaving clinical effectiveness and safety uncertain.
What was evaluated
The review examined curcuminoids taken together with piperine. Its results therefore concern the combination. The abstract does not identify control treatments, doses or exact supplementation durations, which limits how specifically the findings can be interpreted.
Subgroup claims need detail
The authors reported more pronounced changes in longer studies and in certain clinical groups. The abstract does not supply subgroup estimates or comparison tests, so these observations do not establish who benefits most.
The original publication
Effects of Curcuminoids Plus Piperine Co-Supplementation on Serum Lipid Profile in Adults: A Systematic Review and Meta-Analysis of RCTs.
Karimi M, Javadi M, Sharifi M et al.
Lipids · 2026
- PubMed ID
- 41057035
- Record checked
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