Vitamin D dose comparisons in preterm infants differed between early and later follow-up
Higher-dose regimens improved some early outcomes, while later vitamin D status and neurodevelopment showed no statistically significant differences between dose groups.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
In preterm infants, higher-dose vitamin D regimens were associated with better early vitamin D status and some other outcomes. Later vitamin D status and neurodevelopment showed no statistically significant differences between dose groups. This abstract-based summary does not establish lasting benefit or an optimal dose; evidence certainty ranged from moderate to very low.
The abstract omits units for blood vitamin D differences and detailed longer-term follow-up schedules. These gaps limit quantitative interpretation and assessment of whether early changes persisted in the infants studied.
Early outcomes beyond vitamin D
Higher-dose groups also had faster growth, fewer bone-mineralisation problems and lower mortality during early follow-up. The abstract does not quantify these outcomes, so the size and precision of those differences cannot be judged here.
What the specific comparison found
The 800 IU/day versus 400 IU/day comparison found less vitamin D deficiency, with no reported rise in vitamin D excess. That result does not establish the best regimen or rule out all possible harms.
The original publication
Short-term and long-term effects of vitamin D supplementation for preterm infants: a systematic review and meta-analysis.
Shin SH, Kim HJ, Heo JS
J Perinatol · 2026
- PubMed ID
- 41057557
- Record checked
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