Melatonin review reports higher clinical pregnancy odds during assisted reproduction
Trials favored melatonin for clinical pregnancy and some embryo measures, but total egg yield remained statistically uncertain.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Among women undergoing assisted reproduction, the pooled trials favored melatonin for clinical pregnancy and some measures of embryo development. Total egg yield did not show a statistically significant difference. These results concern intermediate reproductive outcomes; the abstract reports no live-birth result and does not establish long-term benefits or the best dose.
This abstract-based summary cannot assess full trial methods. Some secondary results varied considerably across studies, and possible publication bias was suggested for mature egg numbers.
What researchers found
Clinical pregnancy
Clinical pregnancy odds were 1.59 times those in comparison groups; comparator treatments and assessment timing were not reported. The interval shows uncertainty.
Reading the pregnancy estimate
Odds compare pregnancies with nonpregnancies within each group; the ratio compares those odds between groups. It does not specify an absolute increase in pregnancy probability, and absolute rates were not reported.
Questions that remain
Dose and treatment-protocol subgroup signals do not establish that a particular dose works better. The abstract also does not provide a live-birth comparison, leaving an important outcome for patients unanswered.
The original publication
Melatonin improved the outcomes of women with ART: a systematic review and meta-analysis of randomized trials.
Wu Y, Huang W, Tang L et al.
Front Reprod Health · 2025
- PubMed ID
- 41064014
- Record checked
AI-assisted research and writing. This explains one selected publication; it is not a complete review of everything known. Our approach.
One more question, understood.
Keep track of the research you’ve explored.