Higher and standard vitamin D groups showed no significant difference in testosterone changes
Among women with early-stage breast cancer, testosterone changes did not differ significantly between higher and standard vitamin D targets during follow-up.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Testosterone changes did not differ significantly between the higher and standard vitamin D groups during follow-up. The analysis concerns a blood hormone measurement in breast cancer survivors. It does not prove the approaches equivalent, establish overall safety, or show how testosterone would change without supplementation, since both groups received vitamin D.
The analysis was limited to women with complete measurements. The abstract gives no confidence interval for the between-group difference, which limits assessment of precision, and neither group served as an unsupplemented comparison.
What researchers found
Between-group comparison of serum testosterone changes
Higher versus standard vitamin D targets over 24 months; no statistically significant difference was detected.
What changed during follow-up
Researchers tracked blood testosterone from baseline through follow-up. Vitamin D levels rose significantly in both groups during supplementation, while the comparison of testosterone changes between the groups was not statistically significant.
A predictor, with an uncertain explanation
Starting testosterone was the most statistically significant predictor of later testosterone patterns. The authors suggested that hormone-suppressive therapy might influence those patterns; the abstract does not establish that explanation or quantify the predictor's effect size.
The original publication
Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors.
Minopoli A, Di Gennaro P, Porciello G et al.
Int J Mol Sci · 2025
- PubMed ID
- 41155322
- Record checked
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