Lifestyle program showed regional brain blood-flow differences in early Alzheimer's disease
A small interim analysis found regional differences, while whole-brain blood flow and a diabetes-risk index did not differ between groups.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
This abstract-based analysis found higher blood flow in selected brain regions in the active group, without a between-group difference in whole-brain blood flow or the QUICKI diabetes-risk index. Greater adherence was associated with better regional blood flow and QUICKI results, but that association does not establish that adherence caused the differences.
The sample was small, and this was a mid-trial analysis. The abstract reports physiological markers without cognitive outcomes or effect sizes, limiting conclusions about symptom improvement or Alzheimer's disease progression.
What researchers found
ASL-MRI brain blood-flow measurement
Active program versus control at the reported post-trial assessment; whole-brain blood flow did not differ. Effect sizes were not given.
What differed between groups
Both groups received recommendations and medical care. The active group also received coaching, exercise training, and supplements. Because these additions were bundled together, the comparison cannot identify which component accounted for regional blood-flow differences.
Adherence is a separate analysis
People with higher adherence scores had better regional blood-flow results and improved QUICKI scores. However, adherence itself did not differ between trial arms, and these adherence associations should be distinguished from the intervention comparison.
The original publication
A multi-modal medical management and lifestyle intervention increase cerebral blood flow and lowers diabetic risk in persons with early Alzheimer's disease: Mid-trial results from the PREVENTION trial.
Bramen JE, Siddarth P, Popa ES et al.
J Alzheimers Dis · 2025
- PubMed ID
- 41243261
- Record checked
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