Adropin levels were linked to blood pressure variability in older adults
An analysis of repeated blood pressure measurements found an association with a circulating protein, especially among people taking blood pressure medication.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Higher adropin levels were associated with greater variation in systolic blood pressure across visits. The relationship was more apparent among people taking antihypertensive medication, although another analysis suggested a weaker relationship without medication too. These associations do not show that adropin causes unstable pressure or that measuring it improves care.
Observational associations cannot establish cause. The abstract does not show whether adropin adds useful information to clinical assessment or predicts health outcomes beyond the measured blood pressure variability.
What researchers found
Systolic blood pressure variability
Higher versus lower adropin over 5 years; variability was assessed using variation independent of the mean.
Variability differs from pressure level
The central result concerned how systolic pressure varied between visits, using a measure called variation independent of the mean. It should not be read as evidence that adropin raised average blood pressure or caused cardiovascular disease.
Medication subgroups gave different pictures
Regression analyses suggested that the association was concentrated among medication users. Grouping participants by adropin or pressure variability suggested a weaker association without medication too, so the abstract does not support an absolute treated-versus-untreated divide.
The original publication
High circulating adropin levels predict long-term blood pressure variability in old adults: evidence from the Multidomain Alzheimer Prevention Trial.
Aggarwal G, Salas J, Vellas B et al.
Am J Physiol Heart Circ Physiol · 2025
- PubMed ID
- 41252423
- Record checked
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