Low free testosterone tracked poorer survival while awaiting liver transplantation
In men with advanced chronic liver disease, low free testosterone was associated with mortality after adjustment for disease severity.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Low free testosterone was associated with higher mortality among men with advanced chronic liver disease awaiting transplantation, even after adjustment for a disease-severity score. Low total testosterone did not show a statistically clear mortality association. These observations concern prognosis in a specific clinical group and do not establish that changing testosterone levels would improve survival.
The abstract does not report follow-up duration or the cutoff defining low free testosterone. Its observational design cannot determine whether the hormone level contributes to mortality or reflects other illness-related factors.
How survival was analyzed
The researchers treated liver transplantation as a competing event when analyzing deaths. This accounts for transplantation within the mortality analysis, and the reported association for free testosterone was adjusted using a liver-disease severity score.
The hormone groups also differed
Men with low free testosterone had more frailty and signs of more severe liver disease. They also had a lower reported probability of transplantation; these accompanying differences are relevant when interpreting testosterone as a possible prognostic marker.
The original publication
Free Testosterone Is Associated With Worse Survival in Patients With Advanced Chronic Liver Disease Awaiting Liver Transplantation.
Sogbe M, Bromfield B, Tellez R et al.
Liver Int · 2025
- PubMed ID
- 41291391
- Record checked
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