Replacing fats and sugars with avocado changed some blood lipids
Replacing selected fats and sugars with avocado improved some lipid measures, while glucose, insulin and blood-pressure results were not significantly different.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
Replacing some saturated fat and added sugar with avocado lowered the trial's primary lipid measure, non-HDL cholesterol, relative to the control diet. Several other lipid measures also improved. However, changes in glucose, insulin and blood pressure were not significantly different between diets, and the abstract reports risk markers rather than cardiovascular events.
This abstract-based summary covers short diet periods in adults with elevated triglycerides. It cannot establish lasting cardiovascular effects or separate adding avocado from removing the foods it replaced.
What researchers found
Non-HDL cholesterol percentage-change comparison
Avocado versus control diet after each 3-week period; model-estimated comparison of percentage changes from baseline.
A food substitution test
Both diets delivered ingredients through similar prepared foods. The comparison tested a food substitution at equivalent energy intake, so it cannot isolate avocado from the accompanying reductions in saturated fats and added sugars.
Results differed across measures
Triglycerides and several cholesterol measures showed statistically significant differences. Other lipoprotein measures did not. The findings therefore describe a mixed laboratory response rather than improvement across every measured outcome.
The original publication
Effects of replacing solid fats and added sugars with avocado in adults with elevated cardiometabolic risk: a randomized, double-blind, controlled feeding, crossover trial.
Gletsu-Miller N, Wilcox ML, Spence LA et al.
Am J Clin Nutr · 2026
- PubMed ID
- 41397527
- Record checked
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