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Supervised exercise improved quality of life, with substance-use effects still uncertain

A review of randomized trials found better quality-of-life scores with exercise, but urine drug testing did not establish reduced substance use.

By 100HP editorialAbstract-based explanation checked

Based on the published abstract. The full paper may contain additional methods, results and limitations.

The 30-second takeaway

Exercise alongside treatment improved physical, psychological, and social quality-of-life scores in people with substance use disorders. The pooled result for positive urine drug screens was not statistically significant. Feeling or functioning better is a different outcome from reduced substance use, and this review does not establish improvement in both.

Keep in mind

Only some studies entered the pooled analysis. The abstract omits participant totals, treatment durations, and substance-specific results, limiting judgments about applicability.

THE NUMBERS, WITH CONTEXT

What researchers found

Risk ratio 0.79 (95% CI 0.56–1.12); P = .18

Participants with positive urine drug screens

Exercise versus standard treatment; assessment timing unspecified. Estimated risk was 0.79 times control risk; the interval includes lower risk, equal risk, and higher risk.

Medicine (Baltimore), 2025 · Original source ↓

Quality of life was distinct

The review examined supervised exercise in people receiving care for substance use disorders. Quality-of-life findings covered physical, psychological, and social domains, each distinct from substance-use outcomes.

An uncertain drug-test result

Equal risk is the reference for this comparison. The confidence interval spans lower and higher risk of a positive test, leaving both a reduction and equivalence unproven.

CHECK THE ORIGINAL

The original publication

Supervised exercise as adjunctive treatment for substance use disorder: Systematic review and meta-analysis.

Alserihi AR, Abdullah AM, Bashrahil B et al.
Medicine (Baltimore) · 2025

PubMed ID
41465930
Record checked

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