Particle pollution is associated with molecular signs of oxidative stress
Across studies of adults, exposure was linked to molecular changes, although some studies found no statistically significant associations.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The review links particle pollution exposure with molecular patterns related to oxidative stress, including changes in metabolites, chemical marks on genes and microbial communities. Results were not uniform: some studies found no significant associations. These findings concern biological markers and pathways; they do not establish that the reported molecular changes cause disease or quantify a person's health risk.
The abstract reports inconsistent findings but no combined effect estimates, exposure contrasts or follow-up durations. It also does not provide the results of its study-level risk-of-bias assessments.
Several layers of measurement
Researchers examined studies using different molecular approaches. Reported associations included altered antioxidant pathways, energy metabolism and chemical marking of genes, as well as changes in the gut and nasal microbial communities.
Interpreting the mixed evidence
Looking across molecular layers can reveal recurring patterns, but it does not make every study agree. The abstract describes broad associations without enough detail to compare their magnitude across exposure levels or measurement methods.
The original publication
Multi-omics of oxidative stress and particulate matter exposure: a systematic review.
Fallahzadeh A, Mahmoodi T, Kwon S et al.
Respir Res · 2026
- PubMed ID
- 41526934
- Record checked
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