Radiosurgery review separates tumor control from hormonal remission in Cushing’s disease
In persistent or recurrent disease, tumor control was common, but hormonal remission was less frequent and could take time. Recurrence and new pituitary hormone deficiencies remained relevant outcomes.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The review reported high tumor control after stereotactic radiosurgery, but biochemical remission was a separate and less frequent outcome. Remission took time, and some patients later relapsed. New pituitary hormone deficiencies were also reported. These results concern persistent or recurrent Cushing’s disease and do not establish how radiosurgery compares with other treatment choices.
The abstract does not describe a comparison group or provide uniform definitions of remission across studies. The authors call for prospective, standardized research, limiting certainty about comparative benefits and harms.
What researchers found
Biochemical remission
After mean follow-up of 61.5 months following the latest radiosurgery cycle; no comparator was reported. Mean time to remission was 26.4 months.
Different treatment outcomes
Tumor control, biochemical remission, and later recurrence describe different aspects of treatment response. A tumor remaining controlled does not necessarily mean excess hormone production has resolved or that remission will persist.
Complications also matter
New pituitary hormone deficiencies occurred in 29.9% of cases. No radiation-related tissue necrosis was reported, but that does not establish an absence of risk. These safety findings matter alongside the reported tumor-control and hormonal outcomes.
The original publication
Radiosurgery in recurrent and persistent Cushing's Disease: a Systematic Review and Meta-Analysis.
Valeri F, Mastropasqua V, Della Pepa GM et al.
Neurosurg Rev · 2026
- PubMed ID
- 41577859
- Record checked
AI-assisted research and writing. This explains one selected publication; it is not a complete review of everything known. Our approach.
One more question, understood.
Keep track of the research you’ve explored.