Compression stockings reduced leg-cramp frequency in a randomized trial
Stockings outperformed placebo pills on weekly cramp frequency; magnesium did not show a statistically significant difference from placebo.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
In adults with frequent leg cramps, compression stockings reduced cramp frequency compared with placebo pills at the main assessment. Magnesium did not show a statistically significant advantage over placebo. The abstract supports a benefit for stockings on this measured outcome, while leaving the size and durability of broader benefits uncertain.
The trial was only partially blinded, and the abstract does not quantify the reported improvements in pain or cramp-related awakenings.
What researchers found
Baseline-adjusted mean difference in leg-cramp frequency
Stockings versus placebo pills at week 8; 95% CI -2.36 to -0.50.
What the trial tested
Participants had recurring cramps before enrollment. Researchers assigned daily stockings, magnesium, or placebo pills, then evaluated changes in weekly cramp frequency. Pain and awakenings caused by cramps were secondary outcomes.
Tolerance and uncertainty
Four participants stopped using stockings because of adverse reactions, although no serious adverse events were reported. The magnesium comparison was statistically inconclusive; it does not establish that magnesium and placebo have identical effects.
The original publication
Secondary prevention of leg cramps using compression stockings or magnesium supplements: a three-arm randomized clinical trial.
Kuusipalo A, Laitila J, Lehtonen E et al.
Trials · 2026
- PubMed ID
- 41680812
- Record checked
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