Polyamines and gut aging: a biological pathway needing clinical validation
A narrative review explores how diet and microbes influence compounds involved in intestinal repair, drawing on experimental, animal and emerging human research.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
This narrative review describes how diet, gut microbes and polyamines may interact as the intestine ages. It brings together experimental, animal and emerging human research on tissue renewal, inflammation and the gut barrier. The abstract presents a biological rationale for further study, without establishing that a food or supplement improves intestinal aging in people.
The abstract does not describe a systematic search, evidence-quality assessment or quantified human outcomes. This abstract-based account therefore cannot judge how consistently the proposed mechanisms translate into benefits for people.
What polyamines contribute to the question
Polyamines are compounds discussed here in relation to intestinal cell growth, repair and immune regulation. The review considers both the body's own production and production by gut microbes, and how these processes change with age.
Dietary possibilities remain research questions
Fermented foods, prebiotics and probiotics are examined as possible ways to influence microbial polyamine production. These proposed routes connect diet with gut biology, but the authors call for clinical studies to validate their relevance.
The original publication
The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications.
Mafe AN, Büsselberg D
Nutrients · 2026
- PubMed ID
- 41754095
- Record checked
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